Isolation and characterization of kidney-derived stem cells
S Gupta, C Verfaillie, D Chmielewski… - Journal of the …, 2006 - journals.lww.com
Acute kidney injury is followed by regeneration of damaged renal tubular epithelial cells.
The purpose of this study was to test the hypothesis that renal stem cells exist in the adult
kidney and participate in the repair process. A unique population of cells that behave in a
manner that is consistent with a renal stem cell were isolated from rat kidneys and were
termed multipotent renal progenitor cells (MRPC). Features of these cells include spindle-
shaped morphology; self-renewal for> 200 population doublings without evidence for …
The purpose of this study was to test the hypothesis that renal stem cells exist in the adult
kidney and participate in the repair process. A unique population of cells that behave in a
manner that is consistent with a renal stem cell were isolated from rat kidneys and were
termed multipotent renal progenitor cells (MRPC). Features of these cells include spindle-
shaped morphology; self-renewal for> 200 population doublings without evidence for …
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